Journal: Frontiers in Neuroinformatics

Article Title: Embedding Task-Based Neural Models into a Connectome-Based Model of the Cerebral Cortex

doi: 10.3389/fninf.2016.00032

Figure Lengend Snippet: Graphical representation of the locations where visual LSNM modules were embedded, relative to the location of the 998 nodes (smaller gray spheres) comprising the structural connectome of Hagmann et al. , as represented in TVB . The larger spheres represent the location of the visual processing LSNM modules, as indicated with colored labels. Connections among LSNM modules and among nodes are not shown but were preserved upon embedding.

Article Snippet: Recently, a software platform called The Virtual Brain (TVB) has become available that facilitates applying LSNM to neuroimaging data in a whole brain framework (Jirsa et al., ; Ritter et al., ; Sanz Leon et al., , ).

Techniques:

Journal: Frontiers in Neuroinformatics

Article Title: Embedding Task-Based Neural Models into a Connectome-Based Model of the Cerebral Cortex

doi: 10.3389/fninf.2016.00032

Figure Lengend Snippet: Graphical depiction that shows how a given LSNM module was embedded into a TVB node . (A) An LSNM module is composed of several neuronal population units (red circles) and we find the TVB node (purple circle with incoming connections) that is closest to the hypothesized Talairach location of the LSNM module. Several other nodes in TVB have connections to the designated “host” node (blue arrows); (B) we embed the LSNM module by connecting all TVB nodes that have connections to the host TVB node to the embedded LSNM units.

Article Snippet: Recently, a software platform called The Virtual Brain (TVB) has become available that facilitates applying LSNM to neuroimaging data in a whole brain framework (Jirsa et al., ; Ritter et al., ; Sanz Leon et al., , ).

Techniques:

Journal: Frontiers in Neuroinformatics

Article Title: Embedding Task-Based Neural Models into a Connectome-Based Model of the Cerebral Cortex

doi: 10.3389/fninf.2016.00032

Figure Lengend Snippet: (A) Simulated fMRI BOLD signals, using the balloon hemodynamic response model, in combined LSNM/TVB modules, corresponding to the representative subject's integrated synaptic activity shown in Figure . Thirty-six trials were simulated, in groups of six task (DMS) trials (black areas) followed by six control (CTL) trials (gray areas). The x-axis represents time in seconds and the y-axis is in arbitrary units. The simulated TR is 2 s. (B) Bar graphs representing the mean signal change of timepoints 4, 5, and 6 after onset of a block of trials for each condition across 10 simulated subjects. In each ROI, the mean of the within-subject difference between the DMS and CTL conditions was statistically significant (see Table ). Error bars indicate standard errors.

Article Snippet: Recently, a software platform called The Virtual Brain (TVB) has become available that facilitates applying LSNM to neuroimaging data in a whole brain framework (Jirsa et al., ; Ritter et al., ; Sanz Leon et al., , ).

Techniques: Activity Assay, Control, Blocking Assay